Lisdexamphetamine (Vyvanse) is the new kid on the block and in recent years its use has become rampant among many parts of the population (particularly in the US).
Lisdexamphetamine is a prodrug of dextroamphetamine. Compared to instant-release amphetamine (Adderall), it has a smoother onset and offset, less abuse potential, and slightly fewer side effects. Nonetheless, coming off is just as hard, and (potential) adverse effects on long-term brain health may be the same.
I discuss a couple of principles I followed for “responsible” stimulant use here.
Personal experience
I have tried lisdexamphetamine a couple of times at low doses. Even 10mg (3mg dexamphetamine equivalent) made me overly speedy, though I liked the experience. However, the day after I was always quite tired and “meh”.
Three anecdotes from friends:
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