I have discussed the difference between “cellular” longevity and organ health in Part II & Part III of my article on longevity.
If one of my organ systems gives in in isolation, even if all other things were otherwise impeccable, this would cause rapid and massive ripple effects eventually leading to body-wide impairment.
The usual causes of organ degeneration are the following:
- infarction (e.g., pulmonary degeneration after thromboembolism)
- infection (e.g., HBV targeting the liver)
- toxicity (e.g., tadalafil leading to ototoxicity)
- cancer (e.g., liver cancer)
Tactics I follow to support & monitor organ health
- General health
- Monitoring blood markers
- Regenerative medicine
General health
Obviously, many of the things discussed in My Longevity Protocol (Long & Technical Version) will help with maintaining my organs’s health and integrity. These include lowering the mTOR pathway, optimizing metabolic health, keeping my CVS as functional as possible, maintaining high-ish levels of anabolic hormones, lowering inflammation, preventing metals from accumulating, and trying to prevent cancer.
Monitoring blood markers
I monitor many organ markers and am ready to intervene accordingly including liver enzymes (ALT, AST, GGT), uric acid, creatinine, cystatin C, bone mineral density, spermiogram, hematological parameters, hormone markers, CRP, fibrinogen, tumor markers.
Regenerative medicine
Eventually, one or more of my organs will be impaired. Barring existential catastrophe or premature death, in a couple of decades I plan on using various approaches of regenerative medicine if they happen to be available and given we have enough data. These potentially include stem cell replacement, tissue engineering, nanotechnology, and gene therapies. I discuss some of these in more detail here: The Exciting Future of Longevity Medicine
My Longevity Protocol (Long & Technical Version)
This article is part of a much larger post describing my complete longevity blueprint. For my full protocol, read here.
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Sources & further information
- Podcast: Andrew Huberman & Peter Attia – Exercise, Nutrition, Hormones for Vitality & Longevity
- Scientific article: Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring
- Scientific article: The ageing kidney: Molecular mechanisms and clinical implications
Disclaimer
The content on this website represents the opinion and personal experience of the author and does not constitute medical advice. The author does not endorse the use of supplements, pharmaceutical drugs, or hormones without a doctor’s supervision. The content presented is exclusively for informational and entertainment purposes. Never disregard professional medical advice or delay in seeking it because of something you have read on the internet.