Main articles
Protocols & Lifestyle
- My Vitality Protocol
- My Longevity Protocol
- My Longevity Protocol (Long & Technical Version)
- Strategies I Use For Self-improvement, Productivity, and Well-being
- My Supplement Protocol
- How I Optimize My Sleep
- My Fitness Protocol
- My Approach to Exercise
- Blood Tests I Do
- A Short List of Biological Interventions That Improved My Life
- My Experience With Hormone Therapies
- What Changed in 2024?
Diets
- My Approach to Diet
- Why I Stopped Intermittent Fasting
- How Multi-Day Fasting Has Harmed Me
- My Experience With Caloric Restriction
- My Experience With the Ketogenic Diet
Hormones
- Semaglutide
- Thyroid hormones
- Testosterone (TRT)
- My TRT Lite Protocol
- Cortisol
- Leptin
- Other hormones (GH, Insulin, EPO, Estrogel, Oxandrolone, Oxytocin, etc.)
- Low-Dose Finasteride to Lock In My Prime
Antidepressants & related molecules
- Moclobemide
- Bupropion
- Vortioxetine
- Psychedelics
- Microdosing Psychedelics
- Ketamine
- Tianeptine (& Thoughts on Opioids)
- S-adenosyl-methionine (SAMe)
Stimulants
- Principles For Responsible Use
- Modafinil
- Caffeine
- Nicotine
- Hydrocortisone
- Selegiline
- Methylphenidate
- Amphetamine
- Lisdexamphetamine
- Ephedrine
- Reboxetine
- Yohimbine
- Pitolisant
Others molecules
- L-Theanine
- Ibuprofen
- Low Dose Naltrexone (LDN)
- Rapamycin
- Metabolic Drugs
- Hypnotics (“Sleeping Pills”)
- Why I Do Not Take Herbal Supplements
- Piracetam & Racetams
- Midodrine
- Why I Do Not Use Peptides
- NSI-189
Longevity Protocols
- My General Longevity Framework
- My Most Likely Cause of Death – My Protocol for Fighting Atherosclerosis
- The Ultimate Frontier – My Protocol for Fighting Cancer
- My Protocol for Fighting Dementia – What I Do To Keep Brain Health Optimal
- My Approach to Hormone Optimization for Longevity
- Crucially Important & Underrated – My Protocol for Optimizing Metabolic Health
- What Is All the Fuss About mTOR?! – Why (and How) I Reduce the Activity of the mTOR Pathway
- Eliminating Zombie Cells – My Protocol for Fighting Senescent Cells
- Burning to Death – My Protocol for Lowering Inflammation
- My Physical Fitness Protocol
- My Protocol For Optimizing Organ Health
- Avoiding Toxins & Minimizing Infections
- My Protocol For Optimizing Mental Health
- What Genetic Tests Told Me About My Health & Longevity
- Side Effects of My Longevity Protocol
Neuroscience
Neurobiochemistry & Mental Health
- A Smart Guide to Choosing the Right Antidepressant
- The Mind is What the Brain Does – A Story About MDMA
- The Brutal Neglect of Dopamine
- Anhedonia & A Long List Of Potential Interventions
- Case Reports
- Depression – Basic Principles
- What the Hell is Wrong With Modern Psychiatry?
- Is It Safe to Take Stimulants and Antidepressants Forever?
- Kicking Addictions – Potentially Helpful Agents
- ADHD – To Treat or Not to Treat?
- “I Am Tired All The Time” – 13 Reasons Why
- Random Notes on Psychiatry
Neuropharmaceuticals
- Are SSRIs as Bad as Their Reputation?
- Thoughts on Irreversible MAO Inhibitors
- Psychedelics Are Not Toys – 5 Major Risks
- Thoughts On Weed (THC)
- Hypnotics (“Sleeping Pills”)
- Why Does Nobody Talk About Hallucinogen Persistent Perception Disorder?
- Stimulants – Principles for Responsible Use
- Thoughts On Antipsychotics & Mood Stabilizers
- Is Adderall/Vyvanse Neurotoxic?
- How Neurotoxic is MDMA?
- Ketamine Is Probably More Neurotoxic Than You Think
- Mighty Molecules Stuck in Pharmaceutical Pipelines
Longevity
- Longevity Protocols
- My Experience With Rapamycin
- Ranking of Longevity Interventions
- Is Aging “Programmed”?
- The Exciting Future of Longevity Medicine
- Three Fascinating Avenues to Revolutionize Cancer Treatment
Diet, Weight Loss, Metabolic Health
- Why Weight Loss is not About “Calories In vs. Calories Out”
- The Ketogenic Diet Affects Physiology in the Deepest Possible Way
- Metabolic Drugs
- The Seven Pillars of Metabolic Health
- Why I Stopped Intermittent Fasting
- My Experience With Caloric Restriction
- How Multi-day Fasting Has Harmed Me
- Strategies I Use to Keep My Insulin Sensitivity High Year-Round
- Thoughts On Protein, Meat, Salt, Sugar, Fruits, Artificial Sweeteners, Fiber, Dairy, Grains, and Legumes
Other
- The World’s Most Expensive Eating Disorder
- From Severe Long-COVID to Ironman Training in 18 Months
- The 1% Method: “Gentle” Enhancements Can Lead to Non-gentle Results
- Some Philosophy
- Biohacking Can’t Beat Genetics
- Long-term Side Effects of my Addiction to Cold Showers
- The Most Overrated Field in Medicine
- Why I Avoid Herbal Supplements
- Mindset: The “Top-down” Component
- Are Psychiatric Disorders “Real”?
- The Only Proven Longevity Supplement
- How to Develop Super Bones
- If I Had A Billion Dollars…
- What I’d Take: My Drug Preferences for Common Health Problems
- Paradise Engineering: The AGI Aspect I am Most Excited About
- Speculating on the Origins of Elon Musk’s Impulsivity
- Every Intervention Is A Complex Calculation of Tradeoffs
- Why Does Cocaine Make You Cocky and Why Do Psychedelics Make You Weird?
- Project Voice Attractiveness
- Anecdotes From the Most Obsessive Period of My Life
- Cosmetic Surgery vs. Cosmetic Neuropharmacology
- And Soon It Will Be Forgotten…
- Should We Create an Ozempic for Libido?
- The Syndrome of the Ultra Fit
- My LongCOVID Prevention Protocol(Updated Version)
- The Setpoint Trap: A New Way to Think About ME/CFS
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For a full list of topics covered, see here.
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