Articles currently under revision are shown in blue while articles that are already published are shown in red. To get notified of new releases, sign up for the Desmolysium newsletter.
Subscribe to the Desmolysium newsletter and get access to three exclusive articles!
Main articles
Protocols & Lifestyle
- My Vitality Protocol
- My Longevity Protocol
- My Longevity Protocol (Long & Technical Version)
- Strategies I Use For Self-improvement, Productivity, and Well-being
- My Supplement Protocol
- How I Optimize My Sleep
- My Approach to Exercise
- Blood Tests I Do
- A Short List of Biological Interventions That Improved My Life
- My Experience With Hormone Therapies
Diets
- My Approach to Diet
- Why I Stopped Intermittent Fasting
- How Multi-Day Fasting Has Harmed Me
- My Experience With Caloric Restriction
- My Experience With the Ketogenic Diet
Hormones
Antidepressants & related molecules
- Moclobemide
- Bupropion
- Vortioxetine
- Psychedelics
- Microdosing Psychedelics
- Ketamine
- Tianeptine (& Thoughts on Opioids)
- S-adenosyl-methionine (SAMe)
Stimulants
- Principles For Responsible Use
- Modafinil
- Caffeine
- Nicotine
- Hydrocortisone
- Selegiline
- Methylphenidate
- Amphetamine
- Lisdexamphetamine
- Ephedrine
- Reboxetine
Others molecules
- L-Theanine
- Ibuprofen
- Low Dose Naltrexone (LDN)
- Rapamycin
- Metabolic Drugs
- Hypnotics (“Sleeping Pills”)
- Why I Do Not Take Herbal Supplements
- Piracetam & Racetams
- Midodrine
Longevity Protocols
- My General Longevity Framework
- My Most Likely Cause of Death – My Protocol for Fighting Atherosclerosis
- The Ultimate Frontier – My Protocol for Fighting Cancer
- My Protocol for Fighting Dementia – What I Do To Keep Brain Health Optimal
- My Approach to Hormone Optimization for Longevity
- Crucially Important & Underrated – My Protocol for Optimizing Metabolic Health
- What Is All the Fuss About mTOR?! – Why (and How) I Reduce the Activity of the mTOR Pathway
- Eliminating Zombie Cells – My Protocol for Fighting Senescent Cells
- Burning to Death – My Protocol for Lowering Inflammation
- My Physical Fitness Protocol
- My Protocol For Optimizing Organ Health
- Avoiding Toxins & Minimizing Infections
- My Protocol For Optimizing Mental Health
- What Genetic Tests Told Me About My Longevity
- Side Effects of My Longevity Protocol
Neuroscience
Neurobiochemistry & Mental Health
- What Kind of Antidepressant Should I Choose?
- The Power of Neurobiochemistry
- The Brutal Neglect of Dopamine
- Anhedonia & A Long List Of Potential Interventions
- Case Reports
- Depression – Basic Principles
- What the Hell is Wrong With Modern Psychiatry?
- Is It Safe to Take Stimulants and Antidepressants Forever?
- Kicking Addictions – Potentially Helpful Agents
- ADHD – To Treat or Not to Treat?
- “I Am Tired All The Time” – 13 Reasons Why
Neuropharmaceuticals
- Thoughts on SSRIs
- Thoughts on Irreversible MAO inhibitors
- Psychedelics Are Not Toys – 5 Major Risks
- Thoughts On Weed (THC)
- Stimulants of Abuse: Speed, MDMA, Cocaine, Meth
- Hypnotics (“Sleeping Pills”)
- Hallucinogen Persistent Perceptive Disorder – and Other Potentially Permanent Effects of Psychedelics
- Stimulants – Principles for Responsible Use
- Thoughts On Antipsychotics & Mood Stabilizers
- “Adderall/Vyvanse Changed My Life”…But Will It Wreck Your Brain?
- Is Ketamine Neurotoxic?
- Mighty Molecules Stuck In Pharmaceutical Pipelines
Longevity
- Longevity Protocols
- My Experience With Rapamycin
- Ranking of Longevity Interventions
- Is Aging “Programmed”?
- The Exciting Future of Longevity Medicine
- Three Fascinating Avenues to Revolutionize Cancer Treatment
Diet, Weight Loss, Metabolic Health
- Why Weight Loss is not About “Calories In vs. Calories Out”
- Metabolic Drugs
- Metabolic Health – And the Six Pillars of Improving It
- Strategies I Use to Keep My Insulin Sensitivity High Year-Round
- Thoughts On Protein, Meat, Salt, Sugar, Fruits, Artificial Sweeteners, Fiber, Dairy, Grains, and Legumes
Other
- My Long-COVID Prevention Protocol
- The 1% Method: “Gentle” Enhancements Can Lead to Non-gentle Results
- Some Philosophy
- Biohacking Can’t Beat Genetics
- Long-term Side Effects From my Addiction to Cold Showers
- Thoughts On the Microbiome
- Why I Avoid Herbal Supplements
- Mindset: The “Top-down” Component
- Are Psychiatric Disorders “Real”?
Browse By Topic
For a full list of topics covered, see here.