Article collections
Protocols
- My vitality protocol
- My longevity protocol
- My longevity protocol (long & technical version)
- My non-biological approach to self-Improvement, productivity, and well-being
- My supplement protocol
- My sleep optimization protocol
- My exercise protocol
- My approach to diet
- My approach to blood testing
- A short list of biological interventions that improved my life
- How “gentle” enhancements can lead to non-gentle results
- “I Am Tired All The Time” – 13 Reasons Why
Ethics & philosophy
- Guiding principles
- Some philosophy
- On Butterflies, Upwards Spirals, and the Most Powerful Force in the Universe
Vitality
- Understanding “baseline vitality”
- The importance of neurobiochemistry
- Ranking of vitality interventions
- My vitality protocol
Longevity
- A brief history of human lifespan
- What is aging and why do we age?
- How to fight aging
- Is aging “programmed”?
- My longevity protocol
- My longevity protocol (long & technical version)
- Ranking of longevity interventions
- The exciting future of longevity medicine
- Concluding thoughts on aging
Longevity strategies & tactics
- How I fight atherosclerosis
- How I try to prevent cancer from arising
- What I do to delay dementia
- How I optimize my hormones for longevity
- How I improve my metabolic health
- Why and how I downregulate the mTOR pathway
- My experience with rapamycin
- My experience with senolytic drugs
- How I lower inflammation
- How I maintain decent VO2 max, muscle mass, strength, and mobility
- How I optimize organ health
- Thoughts on toxins
- How I minimize infections
- Interesting takeaways from my genetic tests
- Putting a prime on mental health
- Side effects and setbacks
- I am flying blind…
Potentially controversial opinions
- My Long-COVID prevention protocol
- Why I do not take herbal supplements
- Thoughts on modern psychiatry
- Antipsychotics & mood stabilizers
- Thoughts on THC (“weed”)
- Thoughts on the microbiome
- Thoughts on irreversible MAO inhibitors
- Are amphetamines neurotoxic?
- Is ketamine neurotoxic?
- Thoughts on cold exposure & sauna
- My thoughts on quetiapine and olanzapine for the treatment of depression
Lifestyle
- Human connection
- Purpose
- “Mindset”
- My morning routine
- Thoughts on productivity
- Meditation & metta meditation
- Gratitude journaling
- Social media
- Cutting down on phone use
- Getting into flow states
- Psychotherapy
Hormones
- Some general stuff about hormones
- Why are hormones underused?
- My experience with thyroid hormones
- My experience with testosterone (TRT)
- My experience with cortisol
- My experience with leptin
- Strategies I use to optimize my hormones naturally
- Strategies I follow to keep my insulin sensitivity high
- Hormone optimization for longevity
- Hormones & lifespan
- My Experience With “Non-Standard” Hormone Treatments (GH, insulin, EPO, estradiol, oxandrolone, pregnenolone, DHEA, oxytocin, vasopressin)
Metabolic health
- Metabolic health – and the six pillars of improving it
- Ranking of metabolic health interventions
- Metabolic drugs (metformin, acarbose, SGLT-2 inhibitors, semaglutide, rapamycin)
- Insulin & insulin resistance
Cancer
- Strategies I use to avoid cancer
- Cancer biology
- Liquid biopsies
- Immunotherapy
- The future of cancer treatment
Depression & related topics
- What kind of antidepressant should I take?
- Anhedonia & (potential) ways to treat it
- The power of neurobiochemistry
- Humans are complex – case reports
- Atypical vs. melancholic depression
- Evolutionary theories of depression
- Differentiating depression and “suffering”
- Neurobiology of depression
- Why do people get depressed?
- Non-pharmacological treatment of depression
Antidepressants
- The brutal neglect of dopamine
- A case for antidepressants
- Are antidepressants alone sufficient?
- Different kinds of antidepressants
- Practical considerations for antidepressants (e.g., side effects, starting dosage, timing, duration, etc.)
- “Nuclear” options for treatment-resistant cases
- Long-term brain and personality changes when taking antidepressants
- The non-biological effects of antidepressants
- Thoughts on SSRIs
- Thoughts on irreversible MAO inhibitors
Neuropharmacology
- Can stimulants & antidepressants be taken forever?
- Psychiatric polypharmacy
- Noteworthy molecules stuck in pharmaceutical pipelines
- The power of neurobiochemistry
- Noradrenaline
- Dopamine
- Serotonin
- Histamine
- Glutamate
- GABA
- Acetylcholine
- The opioid system
- Pharmacology 101
- What determines the setpoint of neurotransmitters?
The brain
- Neuroplasticity
- Stuff that impairs brain health
- Brain-friendly hobbies
- Tactics I follow to keep my brain young & healthy
- The mind is what the brain does
- Neurobiochemistry & happiness
- Personal thoughts on why having ADHD is not necessarily bad
Psychedelics
- A friend’s experience with psychedelics
- A friend’s experience with microdosing
- Bad trip
- Hippification
- Psychedelic-induced artificial sense of meaning and “truth”
- HPPD – and other potentially permanent effects of psychedelics
Other articles
- Intelligence enhancement
- ADHD – to treat or not to treat?
- Stimulants of abuse – MDMA, cocaine, speed, meth
- Kicking addictions – potentially helpful agents
- Are psychiatric disorders “real”?
- Long-term side effects from an addiction to cold showers
- Biohacking can’t beat genetics
- Treatment options for Long-COVID
- Why Bryan Johnson’s low blood pressure is not an expression of health
Diet
- My diet in more detail
- Why weight loss is not about calories in vs. calories out
- My experience with intermittent fasting
- My experience with the ketogenic diet
- My experience with multi-day fasting
- My experience with caloric restriction
- My experience with metabolic drugs
- Strategies I follow to keep my insulin sensitivity high
- My macronutrient intake
- Thoughts on veganism
- Thoughts on body fat percentage
- Thoughts on protein
- Thoughts on meat
- Thoughts on salt
- Thoughts on sugar
- Thoughts on fruits
- Thoughts on artificial sweeteners
- Thoughts on omega-6 fatty acids
- Thoughts on dairy
- Thoughts on fiber
- Thoughts on grains
- Thoughts on dairy
Exercise
- Exercise, vitality, and the brain
- My exercise protocol (short version)
- My exercise protocol (technical version)
- Thoughts on anabolics
- “Healing like wolverine”
Future of longevity
- Stem cells
- Partial reprogramming
- Gene therapy
- Tissue engineering
- Nanotechnology
- Parabiosis
- New milestones in treating chronic diseases
- Exciting avenues to revolutionize cancer treatment
- Mind uploading
Stimulants (general)
- The dark side of stimulants
- Principles for responsible stimulant use
- How stimulants work
- Why are stimulants pleasurable?
Experience reports (antidepressants)
Experience reports (hypnotics)
- Melatonin
- Zolpidem (Ambien)
- Zopiclone (Lunesta)
- Benzodiazepines
- Pregabalin (Lyrica)
- Trazodone (Trittico)
Experience reports (random)
- Semaglutide (Ozempic)
- Rapamycin
- Senolytics (Dasatinib & Quercetin)
- Ibuprofen
- L-theanine
- Herbal supplements
- S-adenosyl methionine
- Low-dose naltrexone
Experience reports (stimulants)
- MDMA
- Caffeine
- Modafinil
- Nicotine
- Bupropion (Wellbutrin)
- Amphetamine (Adderall)
- Lisdexamphetamine (Vyvanse)
- Methylphenidate (Ritalin)
- Ephedrine
- Selegiline
- Racetams
- Reboxetine
- Midodrine
- Hydrocortisone